原发性干燥综合征患者干眼症越重，其泪液与

摘要:目的：IL-21在原发性干燥综合征（SS）发病机制中起重要作用。本研究目的是评估IL-21在泪液与结膜中的表达水平，分析IL-21对pSS患者干眼症严重程度的影响。方法：本研究共纳入80例受试者，其中30例患者伴干眼症，30例患者不伴干眼症，20例为健康对照者。运用流式细胞仪检测泪液中IL-21水平，用印迹细胞学定量聚合酶链反应检测结膜中的IL-21基因水平。本研究观察所有患者的眼表面疾病指数，泪膜破裂时间，泪液分泌试验，和角膜染色评分。结果：pSS干眼症患者IL-21在泪液以及结膜中表达水平均显著升高(P0.01)。IL-21表达水平在SS不伴干眼症患者以及健康受试者泪液与结膜中无显著差异。在pSS干眼症患者中，泪液IL-21水平与眼表染色值以及泪液分泌试验值有显著相关（分别为r＝0.54，P＜0.01，r=-0.23,P0.05）。结论：本研究结果表明pSS干眼症的严重程度与IL-21水平有相关性。

附原文

Abstract：Purpose:IL-21playsanimportantroleinprimarySj?grensyndrome(SS)pathogenesis.ThepurposeofthisstudywastoevaluateIL-21expressionintearsandtheconjunctivaandtoanalyzetheimpactofIL-21onprimarySSdryeyes.Methods:Eightysubjectswereenrolledinthisstudy:30patientswithprimarySSdryeye(30eyes);30patientswithnon-SSdryeye(30eyes),and20normalcontrols.TearIL-21levelsweremeasuredbyflowcytometry,andIL-21geneexpressionintheconjunctivafromimpressioncytologywasevaluatedbyquantitativepolymerasechainreaction.OcularSurfaceDiseaseIndex,tearfilmbreakuptime,SchirmerItest,andocularsurfacestainingscoreswereobtainedforallpatients.Results:PrimarySSdryeyeshadsignificantlyhighertearIL-21levelsthannon-SSdryeyesandnormalcontrols(P0.01).Inaddition,IL-21geneexpressionintheconjunctivawasalsohigherinprimarySSdryeyesthaninnon-SSdryeyesandnormalcontrols(P0.01).However,therewerenosignificantdifferencesinIL-21expressionintearsandtheconjunctivabetweennon-SSdryeyesandcontrols.ThetearIL-21levelwassignificantlycorrelatedwithocularsurfacestainscores(r=0.54,P0.01)andSchirmerItestvalues(r=-0.23,P0.05)inprimarySSdryeyes.Conclusions:OurfindingssuggestthatseverityofprimarySSdryeyeisassociatedwithIL-21.

引自：LimSA,NamDH,LeeJH，etal.AssociationofIL-21CytokineWithSeverityofPrimarySj?grenSyndromeDryEye.Cornea.Jan19.[Epubaheadofprint]

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